Table.

Genes in Which Mutations Are Reported to Cause Arrhythmogenic Cardiomyopathy

GeneEncoded ProteinSubcellular LocalizationChromosomal Locus
JUPJunction plakoglobinDesmosome17q21.2
DSPDesmoplakinDesmosome6p24.3
PKP2Plakophilin-2Desmosome12p11.21
DSG2Desmoglein-2Desmosome18q12.1
DSC2Desmocollin-2Desmosome18q12.1
TMEM43Transmembrane protein 43 (luma)Nuclear envelope3p25.1
LMNALamin A/CNuclear envelope1q22
DESDesminIntermediate filament2q35
CTNNA3Alpha-T-cateninArea composita10q21.3
PLNPhospholambanSERCA6q22.31
TGFB3Transforming growth factor-3Growth factor14q24.3
TTNTitinSarcomere2q31.2
SCN5ASodium voltage-gated channel alpha subunit 5 (NaV1.5)Sodium channel3p22.2
CDH2Cadherin CArea composita18q12.1