Table 1.

Basal Metabolic Parameters for All Four Mouse Genotypes

HW (Leprdb/+.Nox1+/y)HK (Leprdb/+.Nox1−/y)KW (Leprdb/db.Nox1+/y)KK (Leprdb/db.Nox1−/y)
Body weight, g29±0.628±0.848±3.4*44±3.2
Fasting blood glucose, mg/dL205±16.8184±16.9386±49.1*385±50.9
Fasting plasma insulin, ng/mL0.2±0.020.1±0.011.3±0.17*1.5±0.07
Fasting plasma triglyceride, mg/dL27.5±5.6134.9±4.5283.6±6.94*99.2±17.86
Fasting plasma cholesterol, mg/dL81.7±6.5188.8±10.33165.1±6.51*128.7±11.93
Fasting plasma NEFA, mEq/mL0.56±0.0240.61±0.0390.82±0.067*0.72±0.096
Food consumption, g/d4.2±0.193.7±0.065.4±0.29*5.3±0.29
VCO2, mL·kg·h3446±55.43412±27.31892±36.1*1941±24.7
VO2, mL·kg·h3458±7.93583±24.42034±22.6*1996±45.8
  • NEFA indicates nonesterified fatty acid.

  • * P<0.05 KW vs. HW.

  • P<0.05 KK vs. HK.