Table 1.

Body Weight, Blood Pressure, Heart Rate, and Echocardiographic Measurements at 6 Weeks After Infusion in Wild-Type and ASK1−/− Mice

Wild-TypeASK1−/−
Saline Infusion (n=6)Ang II Infusion (n=7)Saline Infusion (n=6)Ang II Infusion (n=7)
BW indicates body weight; BP, blood pressure; HR, heart rate; LVEDD, left ventricular end-diastolic dimension; LVESD, left ventricular end-systolic dimension; FS, fractional shortening; EF, ejection fraction; IVS, intraventricular septum; PW, posterior wall; and E/A, E wave/A wave.
P<0.05,
*P<0.01 vs saline-infused wild-type mice;
P<0.01 vs Ang II–infused wild-type mice.
BW, g27.3 ±0.4828.2 ±0.3427.5 ±0.8228.0 ±0.36
BP, mm Hg102 ±3121 ±3*103 ±3123 ±3*
HR, bpm683 ±13687 ±12685 ±18691 ±15
Echocardiography
    LVEDD, mm3.29 ±0.113.30 ±0.063.32 ±0.093.27 ±0.10
    LVESD, mm2.07 ±0.092.04 ±0.072.09 ±0.112.02 ±0.16
    FS, %37 ±2.538 ±3.837 ±2.838 ±1.4
    EF72.7 ±3.176.4 ±4.472.3 ±3.574.3 ±2.1
    IVS, mm0.60 ±0.040.79 ±0.04*0.59 ±0.030.67 ±0.05
    PW, mm0.59 ±0.070.76 ±0.06*0.56 ±0.030.65 ±0.02
    E/A1.73 ±0.112.31 ±0.191.82 ±0.081.62 ±0.09