On the cover: Formation of an immunological synapse between a CD4 T cell (center) and a vascular smooth muscle cell (upper left corner). Arrest of the T cell on the VSMC surface is associated with extensive membrane reorganization at the interface. Distributions of T cell antigen receptors (green) and LFA-1 integrin molecules (red) are captured by confocal microscopy. The immunological synapse (yellow) signifies T cell recognition and provides a platform for T cell-VSMC interactio. See page 1168.