On the cover: Minimally oxidized low-density lipoprotein and oxidized cholesteryl esters induce robust membrane ruffling in macrophages. In this issue of the journal, Choi et al. demonstrate that these Toll-like receptor 4-dependent cytoskeletal rearrangements lead to macropinocytosis and lipoprotein uptake by macrophages. Red, filamentous actin; yellow, nucleus. See related article, page 1355.