On the cover: Confocal microscopy analysis of endothelial nitric oxide synthase (eNOS) distribution in human umbilican vein endothelial cells before (left) and after (right) estradiol (E2) treatment. A strong nuclear eNOS localization in response to E2 (right) is shown. Nuclear eNOS localizes on hTERT (the catalytic subunit of human telomerase) promoter in association with the estrogen receptor (ER) bound to the proximal hTERT estrogen receptor response element (ERE) at position −949/−935 relative to the transcription start site (see schematic at top). See related article, page 34.