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About This Cover
Volume 102, Issue 6; March 28, 2008
Editorials
Reports
Reviews
Molecular Medicine
Cellular Biology
Integrative Physiology
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Editorials
PICOT: A Multidomain Scaffolding Inhibitor of Hypertrophic Signal Transduction
Allen M. Samarel
Circ Res. 2008;102:625-627, doi:10.1161/CIRCRESAHA.108.173807
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Angiotensin-Converting Enzyme 2: A New Player in Central Sympathetic Regulation?
Irving H. Zucker
Circ Res. 2008;102:628-629, doi:10.1161/CIRCRESAHA.108.173781
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The Enigma of Sphingosine 1-Phosphate Synthesis: A Novel Role for Endothelial Sphingosine Kinases
Junsuke Igarashi and Thomas Michel
Circ Res. 2008;102:630-632, doi:10.1161/CIRCRESAHA.108.173799
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Reports
Beneficial Effect of the Central Nervous System β-Adrenoceptor Blockade on the Failing Heart
Andrey Gourine, Svetlana I. Bondar, K. Michael Spyer, and Alexander V. Gourine
Circ Res. 2008;102:633-636; published online before print March 6 2008, doi:10.1161/CIRCRESAHA.107.165183
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Reviews
Crosstalk Between Vascular Endothelial Growth Factor, Notch, and Transforming Growth Factor-β in Vascular Morphogenesis
Matthew T. Holderfield and Christopher C.W. Hughes
Circ Res. 2008;102:637-652, doi:10.1161/CIRCRESAHA.107.167171
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Molecular Medicine
Targeting Connexin 43 Prevents Platelet-Derived Growth Factor-BB–Induced Phenotypic Change in Porcine Coronary Artery Smooth Muscle Cells
Christos E. Chadjichristos, Sandrine Morel, Jean-Paul Derouette, Esther Sutter, Isabelle Roth, Anne C. Brisset, Marie-Luce Bochaton-Piallat, and Brenda R. Kwak
Circ Res. 2008;102:653-660; published online before print January 31 2008, doi:10.1161/CIRCRESAHA.107.170472
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Hairy-Related Transcription Factors Inhibit Notch-Induced Smooth Muscle
-Actin Expression by Interfering With Notch Intracellular Domain/CBF-1 Complex Interaction With the CBF-1–Binding Site
Yuefeng Tang, Sumithra Urs, and Lucy Liaw
Circ Res. 2008;102:661-668; published online before print January 31 2008, doi:10.1161/CIRCRESAHA.107.165134
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Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate
Krishnan Venkataraman, Yong-Moon Lee, Jason Michaud, Shobha Thangada, Youxi Ai, Herbert L. Bonkovsky, Nehal S. Parikh, Cheryl Habrukowich, and Timothy Hla
Circ Res. 2008;102:669-676; published online before print February 7 2008, doi:10.1161/CIRCRESAHA.107.165845
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Cellular Biology
c-kit Is Required for Cardiomyocyte Terminal Differentiation
Ming Li, Nawazish Naqvi, Eiji Yahiro, Ke Liu, Pamela C. Powell, Wayne E. Bradley, David I.K. Martin, Robert M. Graham, Louis J. DellItalia, and Ahsan Husain
Circ Res. 2008;102:677-685; published online before print February 7 2008, doi:10.1161/CIRCRESAHA.107.161737
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Regulation of Cardiomyocyte Proliferation and Myocardial Growth During Development by FOXO Transcription Factors
Heather J. Evans-Anderson, Christina M. Alfieri, and Katherine E. Yutzey
Circ Res. 2008;102:686-694; published online before print January 24 2008, doi:10.1161/CIRCRESAHA.107.163428
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Ca
2+
/Calmodulin-Dependent Protein Kinase II
and Protein Kinase D Overexpression Reinforce the Histone Deacetylase 5 Redistribution in Heart Failure
Julie Bossuyt, Kathryn Helmstadter, Xu Wu, Hugh Clements-Jewery, Robert S. Haworth, Metin Avkiran, Jody L. Martin, Steven M. Pogwizd, and Donald M. Bers
Circ Res. 2008;102:695-702; published online before print January 24 2008, doi:10.1161/CIRCRESAHA.107.169755
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Integrative Physiology
Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice
Olesya Vakhrusheva, Christian Smolka, Praveen Gajawada, Sawa Kostin, Thomas Boettger, Thomas Kubin, Thomas Braun, and Eva Bober
Circ Res. 2008;102:703-710; published online before print January 31 2008, doi:10.1161/CIRCRESAHA.107.164558
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PICOT Attenuates Cardiac Hypertrophy by Disrupting Calcineurin–NFAT Signaling
Dongtak Jeong, Ji Myoung Kim, Hyeseon Cha, Jae Gyun Oh, Jaeho Park, Soo-Hyeon Yun, Eun-Seon Ju, Eun-Seok Jeon, Roger J. Hajjar, and Woo Jin Park
Circ Res. 2008;102:711-719; published online before print February 7 2008, doi:10.1161/CIRCRESAHA.107.165985
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Targeting the Calpain/Calpastatin System as a New Strategy to Prevent Cardiovascular Remodeling in Angiotensin II–Induced Hypertension
Emmanuel Letavernier, Joëlle Perez, Agnès Bellocq, Laurent Mesnard, Alexandre de Castro Keller, Jean-Philippe Haymann, and Laurent Baud
Circ Res. 2008;102:720-728; published online before print February 7 2008, doi:10.1161/CIRCRESAHA.107.160077
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Angiotensin-Converting Enzyme 2 Overexpression in the Subfornical Organ Prevents the Angiotensin II–Mediated Pressor and Drinking Responses and Is Associated With Angiotensin II Type 1 Receptor Downregulation
Yumei Feng, Xinping Yue, Huijing Xia, Sharell M. Bindom, Peter J. Hickman, Catalin M. Filipeanu, Guangyu Wu, and Eric Lazartigues
Circ Res. 2008;102:729-736; published online before print February 7 2008, doi:10.1161/CIRCRESAHA.107.169110
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Tunnel Propagation of Postshock Activations as a Hypothesis for Fibrillation Induction and Isoelectric Window
Takashi Ashihara, Jason Constantino, and Natalia A. Trayanova
Circ Res. 2008;102:737-745; published online before print January 24 2008, doi:10.1161/CIRCRESAHA.107.168112
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