On the cover: Syncytial knots, degenerative structures typifying a preeclamptic placenta, are the major source of the novel human-specific soluble VEGF receptor, previously implicated in preeclampsia causation. In situ hybridization of a preeclamptic placenta with a riboprobe specific to the novel soluble VEGF receptor, designated sFlt1-14. See related article, page 1566.