On the cover: Left: A total internal reflection fluorescence microscopy image of YFP fused to phospholamban, expressed in the endoplasmic reticulum (yellow) and plasma membrane (orange) of an AAV-293 cell. Right: Isosurface rendering of CFP-SERCA donor (blue) and YFP-phospholamban acceptor (yellow) fluorescence at a site of acceptor-selective photobleaching. Donor fluorescence enhancement after acceptor photobleaching indicates fluorescence energy transfer. Surfaces were rendered with public domain software ImageJ, using a plugin by Kai Uwe Barthel. See related article, page 1123.