On the cover: The cover shows aortic abnormalities of Fibulin-4^R/R mice (Hanada et al., this issue). Left picture: representative heart, aortic arche and branches of a newborn Fibulin-4^R/R mouse. The aorta of Fibulin-4^R/R mice is elongated, tortuous and severely dilated. Right picture: elastin stains of longitudinal aorta sections according to Verhoeff-Van Gieson showing regions with relatively well-organized elastic laminae, but also regions with dramatically affected laminae in Fibulin-4^R/R mice.

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