On the cover: Superimposed images showing TRPCs mRNA expression (top), a mouse single pacemaker cell (middle) and intracellular Ca²⁺ signal recorded from mouse-sinoatrial node (bottom). The cell is labelled with antibody to TRPC3 (green fluorescence) and with DAPI which labels the nucleus (red fluorescence). The bottom confocal image shows fluo-4 fluorescence from a spontaneously active sinoatrial pacemaker region and shows how the intracellular Ca²⁺ fluctuates with time (red represents low Ca²⁺, yellow indicates high Ca²⁺), which is also clearly indicated as a green line plotted against the time. See related article, page 1605.

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