Proton Pump Inhibitors Accelerate Endothelial Senescence
Rationale: Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal and neurological morbidity.
Objective: To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in PPI induced vascular dysfunction.
Methods and Results: Chronic exposure to PPIs impaired endothelial function and accelerated human endothelial senescence by reducing telomere length.
Conclusions: Our data may provide a unifying mechanism for the association of PPI use with increased risk of cardiovascular, renal and neurological morbidity and mortality.
- telomere length
- lysosomal function
- proton pump inhibitor
- cardiovascular disease risk factors
- Received March 28, 2016.
- Revision received April 12, 2016.
- Accepted April 19, 2016.