The Absence of Evidence Is Not Evidence of Absence: The Pitfalls of Cre Knock-Ins in the C-Kit Locus
c-kit1 cells minimally contribute cardiomyocytes to the heart. van Berlo et al. Nature. 2014. doi:10.1038/nature13309
A recent paper by Jeffrey Molkentin's group using mice with Cre/lox knock-in in the c-kit locus concludes that, contrary to other reports, c-kit+ cells minimally contribute cardiomyocytes to the heart. We believe the authors' interpretation of the results is problematic because critical data to support their conclusions have not been provided.
- Received June 23, 2014.
- Accepted June 23, 2014.