The Circulating Long Non-Coding RNA LIPCAR Predicts Survival in Heart Failure Patients
Rationale: Long non-coding RNAs (lncRNAs) represent a novel class of molecules regulating gene expression. LncRNAs are present in body fluids, but their potential as biomarkers was never investigated in cardiovascular disease.
Objective: Role of lncRNAs as potential biomarkers in heart disease.
Methods and Results: Global transcriptomic analyses were done in plasma RNA from patients with/without left ventricular (LV)-remodeling after myocardial infarction. Regulated candidates were validated in three independent patient cohorts developing cardiac remodeling and heart failure (788 patients). The mitochondrial lncRNA uc022bqs.1 (LIPCAR) was down-regulated early after MI but up-regulated during later stages. LIPCAR levels identified patients developing cardiac remodeling and were independently to other risk markers associated with future cardiovascular deaths.
Conclusions:LIPCAR is a novel biomarker of cardiac remodeling and predicts future death in heart failure patients.
- long non-coding RNAs
- circulating lncRNA
- cardiac remodeling
- myocardial infarction
- heart failure
- cardiac biomarkers
- Received March 10, 2014.
- Revision received March 20, 2014.
- Accepted March 24, 2014.