Dilution Curves of Simultaneously Administered 1131-Human Serum Albumin and Cr51-Labeled Erythrocytes in Patients with Various Types of Edema
Detailed indicator-dilution curves of simul taneously administered 1131-HSA and Cr51-RBC in six of eight edematous patients with congestive heart failure demonstrate that, as in normal patients, a significant quantity of 1 does not escape the intravascular space during the first several minutes post injection. It would seem, therefore, that cap illary permeability to albumin was not an im portant manifestation in these patients. De tailed indicator-dilution curves in five of six patients with edema not associated with con gestive heart failure differ from those derived from normal patients and from the edematous patients with congestive heart failure. These data do not exclude the possibility that capillary permeability to albumin might be a sig nificant concomitant of edema associated with chronic glomerulonephritis, disseminated lupus erythematosis, toxemia of pregnancy. car cinomatosis, and Kimmelstiel-Wilson syndrome.
Dr. Tuekman is a Postdoctoral Research Fellow, National Heart Institute, U. S. Public Health Service. This work
- Received May 15, 1961.
- © 1961 American Heart Association, Inc.