Fibrinolytic Activity of Arterial Tissues
Arterial tissues were studied for plasminogen activator to demonstrate the possible relationship of its deficiency within the arterial wall to atherosclerosis. Activator was found primarily within the adventitia. The enzyme seemed to appear in fetuses at about the 2,000-Gm. stage of development. Different arteries showed varying activity, with the basilar artery showing least activity; the coronary and renal arteries showing the greatest activity; and the aortic arch; abdominal aorta, and pulmonary arteries falling between. The coronary arteries of females and the aortie arches of females under 60 years of age showed greater activity than those of comparable males. The degree of atherosclerotic in volvement of the coronahes or aorta could not be correlated with the level of plasminogen activator.
- Received October 19, 1960.
- © 1961 American Heart Association, Inc.