Articles
The Effect of Digoxin on the Intermediary Metabolism of the Heart as Measured by Glucose-C14 Utilization in the Intact Dog
GERALD ALAN KIEN, THEODORE R. SHERROD
https://doi.org/10.1161/01.RES.8.1.188
Circulation Research. 1960;8:188-198
Originally published January 1, 1960Jump to

Abstract
Administration of a therapeutic dose level of digoxin in the intact dog resulted in an augmentation of the glucose utilization of the myocardium accompanied by a greatly increased rate of glycolytic and oxidative activity. The contribution of glucose to the total metabolism of the heart was increased, and the utilization of noncarbohydrate substrates was decreased. These metabolic changes occurred in the absence of changes in the dynamic functions of the heart, indicating that the metabolic alterations were due to a primary effect of the drug rather than an effect secondary to an altered state of cardiac activity.
- Received August 17, 1959.
- © 1960 American Heart Association, Inc.
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- The Effect of Digoxin on the Intermediary Metabolism of the Heart as Measured by Glucose-C14 Utilization in the Intact DogGERALD ALAN KIEN and THEODORE R. SHERRODCirculation Research. 1960;8:188-198, originally published January 1, 1960https://doi.org/10.1161/01.RES.8.1.188
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