Sodium Gradient and Renoprival Hypertension in the Rat
Following nephrectomy in the rat blood pressure rises while the extracellular fluid volume increases, sodium concentration falls and potassium rises. These changes (without the potassium rise) can be mimicked by simple hyperosmotic loading while the reverse can be induced by dehydration. The rise in blood pressure is not due to either expansion of the extracellular space or the fall in sodium concentration alone but probably to the resultant decrease in the Nao/Na1 gradient.
- Received June 1, 1959.
- © 1959 American Heart Association, Inc.