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ARTICLES

Regional changes in hemodynamics and cardiac myocyte size in rats with aortocaval fistulas. 1. Developing and established hypertrophy.

Z Liu, D R Hilbelink, W B Crockett, A M Gerdes
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https://doi.org/10.1161/01.RES.69.1.52
Circulation Research. 1991;69:52-58
Originally published July 1, 1991
Z Liu
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D R Hilbelink
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W B Crockett
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A M Gerdes
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Abstract

The effects of a large arteriovenous fistula on left and right ventricular hemodynamics and cardiac myocyte size were examined in adult rats at 1 week and 1 month after surgery. Cardiac output, left ventricular function, and right ventricular function were evaluated before obtaining isolated myocytes for cell size measurements. Average heart weight increased 35% at 1 week and 86% at 1 month in rats with fistulas. In general, myocyte hypertrophy was due to a proportional increase in length and width (length/width ratio remained constant). This change was more evident in the large hearts from rats with 1-month fistulas. At both the 1-week and 1-month intervals, the hypertrophic response of right ventricular myocytes was slightly greater than that observed in the left ventricle or interventricular septum. Left ventricular systolic pressure and dP/dtmax were significantly reduced at 1 week but returned to normal after 1 month of overloading. Left ventricular end-diastolic pressure was increased approximately fivefold and twofold at 1 week and 1 month, respectively. Right ventricular systolic pressure and dP/dtmax were increased at both intervals examined. We conclude that severe volume overloading from a large aortocaval fistula in the rat is characterized by 1) depressed left ventricular function at 1 week followed by a large compensatory hypertrophy and near normal function at 1 month, 2) right ventricular pressure overload, and 3) changes in myocyte shape that resemble normal physiological growth.

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Circulation Research
July 1, 1991, Volume 69, Issue 1
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    Regional changes in hemodynamics and cardiac myocyte size in rats with aortocaval fistulas. 1. Developing and established hypertrophy.
    Z Liu, D R Hilbelink, W B Crockett and A M Gerdes
    Circulation Research. 1991;69:52-58, originally published July 1, 1991
    https://doi.org/10.1161/01.RES.69.1.52

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    Regional changes in hemodynamics and cardiac myocyte size in rats with aortocaval fistulas. 1. Developing and established hypertrophy.
    Z Liu, D R Hilbelink, W B Crockett and A M Gerdes
    Circulation Research. 1991;69:52-58, originally published July 1, 1991
    https://doi.org/10.1161/01.RES.69.1.52
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