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ARTICLES

Renin-angiotensin II response to the hemodynamic pathology of ovines with ventricular septal defect.

M M Boucek, R Chang, D P Synhorst
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https://doi.org/10.1161/01.RES.64.3.524
Circulation Research. 1989;64:524-531
Originally published March 1, 1989
M M Boucek
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R Chang
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D P Synhorst
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Abstract

We studied the response of the renin-angiotensin system (RAS) to a surgically created ventricular septal defect (VSD) in immature ovines and also the role of angiotensin II in the pathophysiology of VSD in the chronically instrumented ovine. Plasma renin activity (PRA) was increased from 2.39 +/- 1.1 to 3.78 +/- 1.4 ng/ml/hr (p less than 0.05, n = 17) after VSD but not after sham procedure. The change in PRA was positively correlated with the amount of left-to-right shunt through the VSD (r = 0.74, p less than 0.05). Inhibition of angiotensin II effect with saralasin (10 micrograms/kg/min) or angiotensin II production with captopril (2 mg/kg) lowered systemic resistance (Rs) by 14% and 34%, respectively (p less than 0.05), and raised pulmonary resistance (Rp) by 35% and 77%, respectively (p less than 0.05). Thirty minutes following captopril, the ratio of pulmonary to systemic flow (Qp/Qs) decreased from 3.31 +/- 0.18 to 2.15 +/- 0.18 (p less than 0.05) while total pulmonary flow fell from 7.15 +/- 0.38 to 5.92 +/- 0.34 l/min/M2 (p less than 0.05, n = 11). Systemic flow increased from 2.17 +/- 0.14 to 2.86 +/- 0.33 l/min/M2 (p less than 0.05) despite a reduction in left atrial pressure (17.3 +/- 1.0 vs. 13.0 +/- 1.7, p less than 0.01). Reinfusion of angiotensin II (0.02 micrograms/kg/min) into the central aorta after captopril returned the hemodynamics to baseline including a rise in Rs and fall in Rp. Exogenous angiotensin II alone (0.08 micrograms/kg/min) or a threefold stimulation in PRA with furosemide (2 mg/kg) caused little hemodynamic effect.(ABSTRACT TRUNCATED AT 250 WORDS)

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March 1, 1989, Volume 64, Issue 3
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    Renin-angiotensin II response to the hemodynamic pathology of ovines with ventricular septal defect.
    M M Boucek, R Chang and D P Synhorst
    Circulation Research. 1989;64:524-531, originally published March 1, 1989
    https://doi.org/10.1161/01.RES.64.3.524

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    Renin-angiotensin II response to the hemodynamic pathology of ovines with ventricular septal defect.
    M M Boucek, R Chang and D P Synhorst
    Circulation Research. 1989;64:524-531, originally published March 1, 1989
    https://doi.org/10.1161/01.RES.64.3.524
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