Further Observations on the Effects of Thyroid Hormone Preparations on Cholesterolemia and Atherogenesis in Cholesterol-Fed Cockerels
Administration of large doses of thyroid hormone preparations (desiccated thyroid powder, thyroxine, triiodothyronine, diiodotyrosine) to cholesterol-fed chicks was associated with decreased rate of weight gain and partial inhibition of hypercholesterolemia. Consistent, definitive inhibition of aorta and coronary atherogenesis was not observed, despite partial suppression of hypercholesterolemia. Potassium iodide and thyroid-stimulating hormone of the anterior pituitary were essentially without effect.
- Received June 30, 1958.
- © 1958 American Heart Association, Inc.