Ineffectiveness of Nitroglycerin as an Antiadrenergic Agent on the Cat Heart
The possibility that nitroglyoerin modifies the metabolic effects of the sympathomimetic amines was tested in cats. Changes in the heart rate, blood pressure, height of the electrocardiographic T-wave and myocardial oxygen consumption following the injection of epinephrine or l-arterenol were compared with changes in these indices after nitroglycerin was given with these sympathomimetic amines. The conclusion is reached that nitroglycerin does not significantly influence the effects of epinephrine or l-arterenol on the heart rate, the height of the electrocardiographic T-wave or myocardial oxygen consumption. There is no evidence in these experiments to support the concept that nitroglycerin metabolically neutralizes the myocardial anoxating properties of the sympathomimetic amines.
- Received July 6, 1956.
- © 1956 American Heart Association, Inc.