Splanchnic Hemodynamics and Oxygen Utilization During Hemorrhagic Shock in the Dog
Portal vein and hepatic artery flow were measured with bristle flowmeters. Based on such measurements, oxygen utilization by both the intestine and liver was found to be significantly reduced after prolonged hypotension. Splanchnic vascular resistance did not increase significantly during hypotension, and following transfusion there was a phase of marked reduction particularly in the mesenteric component. This was followed by some degree of compensation which persisted until the terminal stages when splanchnic vascular resistance again declined. Terminally, mesenteric resistance again appeared to be the component of total splanchnic resistance which manifested failure of compensation. It is suggested that impaired oxygen utilization by the intestine and liver may be a key mechanism accountable for the inadequate splanchnic vascular compensation during hypotension and its ultimate failure.
- Received June 11, 1956.
- © 1956 American Heart Association, Inc.