The Effect of Dicumarol on the Transvascular Exchange of T-1824-Labeled Protein in Rabbits
The effect of Dicumarol on the peritoneal transvascular transfer of T-1824-labeled plasma protein was investigated in the intact rabbit by a specially designed method. A significantly increased transfer rate was found in animals given two injections of Dicumarol 48 and 24 hours prior to testing; but determinations made 3 hours after a single injection demonstrated variable susceptibility to the drug. Prothrombin levels were depressed in every case.
- Received December 27, 1955.
- © 1956 American Heart Association, Inc.