Stimulation of Prostaglandin Biosynthesis by Adenine Nucleotides
Profile of Prostaglandin Release by Perfused Organs
Prostaglandin release from various isolated perfused organs is characteristically dependent on the stimulus; thus, certain stimuli caused prostaglandin release in some organs and not in others. Adenosine triphosphate and adenosine diphosphate were potent stimulators of prostaglandin biosynthesis in the kidney, spleen, spleen fat pad, heart, liver and lung; adenosine monophosphate and adenosine were inactive. Epinephrine caused prostaglandin release from the kidney, spleen, and liver, whereas, angiotensin was agonistic in the kidney, spleen, spleen fat pad, and liver. Indomethacin abolished the release (biosynthesis) of prostaglandins from all organs by each agonist.
- fat pad
- rat stomach strip
- chick rectum autoregulation
- adenosine triphosphate
- Received May 4, 1973.
- Accepted January 11, 1974.
- © 1974 American Heart Association, Inc.