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Studies on the Antithrombin and Heparin Co-factor Activities of a Fraction Adsorbed from Plasma by Aluminum Hydroxide
FRANK C. MONKHOUSE, EVELYN S. FRANCE, WALTER H. SEEGERS
https://doi.org/10.1161/01.RES.3.4.397
Circulation Research. 1955;3:397-402
Originally published July 1, 1955FRANK C. MONKHOUSE
EVELYN S. FRANCE
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Abstract
A chemical method has been devised for the quantitative determination of plasma antithrombin. A concentrate of antithrombin has been prepared from plasma. It also contains heparin cofactor activity. The two distinct activities could not be separated and may quite possibly be the properties of a single substance. When the concentrate is combined with heparin the capacity of the concentrate to destroy thrombin is not increased but there is interference with the thrombin fibrinogen interaction. In a mixture of the concentrate and thrombin there is simultaneous destruction of antithrombin, and thrombin activities. Small amounts of the concentrate significantly prolong the clotting time of blood.
- © 1955 American Heart Association, Inc.
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- Studies on the Antithrombin and Heparin Co-factor Activities of a Fraction Adsorbed from Plasma by Aluminum HydroxideFRANK C. MONKHOUSE, EVELYN S. FRANCE and WALTER H. SEEGERSCirculation Research. 1955;3:397-402, originally published July 1, 1955https://doi.org/10.1161/01.RES.3.4.397
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