Effects of Acute and Chronic Digoxin Administration in Dogs with Right-Sided Congestive Heart Failure Produced by Pulmonary Artery Constriction
Acute and chronic responses to digoxin have been studied in dogs with cardiac failure secondary to constriction of the pulmonary artery. Cardiovascular and renal hemodynamic function improved and, frequently, a striking increase in sodium (Na) excretion resulted. The data suggest a direct myocardial action of digoxin and provide evidence of impaired myocardial function similar to that observed in patients with congestive heart failure.
- Received November 22, 1954.
- © 1955 American Heart Association, Inc.