Effect of 1-Epinephrine on the Coronary Circulation in Human Subjects with and without Coronary Artery Disease
The effects of intravenous infusion of epinephrine on the coronary circulation of 21 human subjects, 8 with and 13 without coronary artery disease, have been studied. The response to epinephrine was similar in the two groups. Epinephrine increased cardiac output, stroke volume, and systolic ejection rate significantly without significant change in blood pressure. Myocardial O2 consumption increased in relation to increased kinetics of contraction. Coronary flow increased significantly without change in coronary arteriovenous O2 difference, suggesting that the vasodilatory response to epinephrine in man is secondary to augmented myocardial metabolic demands.
- Accepted November 1, 1967.
- © 1967 American Heart Association, Inc.