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Articles

Post-Countershock Arrhythmias in Untreated and Digitalized Dogs

ROBERT E. TEN EICK, STEVEN R. WYTE, SAMUEL M. ROSS, BRIAN F. HOFFMAN
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https://doi.org/10.1161/01.RES.21.3.375
Circulation Research. 1967;21:375-390
Originally published September 1, 1967
ROBERT E. TEN EICK
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STEVEN R. WYTE
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SAMUEL M. ROSS
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BRIAN F. HOFFMAN
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Abstract

Recent studies suggest that countershock can stimulate cardiac autonomic nerves and that the resulting release of norepinephrine contributes to post-countershock (PCS) arrhythmias. β-Adrenergic receptor blocking agents, reserpine, cocaine, and cardiac-denervated preparations were used to evaluate this hypothesis in dogs under pentobarbital anesthesia. The suitability of the dog as an experimental system was examined. In the normal dog, the duration of PCS arrhythmia caused by a countershock of given energy was increased 100% by ouabain (0.05 mg/kg iv). In both normal dogs and dogs given ouabain (0.05 mg/kg iv), dichloroisoproterenol, pronethalol, and propranolol reduced the duration of PCS arrhythmia; reserpine, a norepinephrine depletor, reduced the duration of PCS arrhythmia; cocaine, a norepinephrine-uptake inhibitor possessing antiarrhythmic properties, increased the duration of PCS arrhythmia; denervation of the heart reduced the duration of PCS arrhythmia. Ouabain (0.05 mg/kg iv) reduced the duration of PCS arrhythmia in dogs with denervated hearts. These findings indicate that PCS arrhythmia in dogs is norepinephrine dependent. Evidence indicated that ouabain has an anti-adrenergic action on the heart also is presented.

  • cardiac catecholamines
  • ouabain
  • βreceptor blockade
  • cardiac denervation
  • reserpine
  • cocaine
  • d-c countershock
  • Accepted July 9, 1967.
  • © 1967 American Heart Association, Inc.
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Circulation Research
September 1, 1967, Volume 21, Issue 3
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    Post-Countershock Arrhythmias in Untreated and Digitalized Dogs
    ROBERT E. TEN EICK, STEVEN R. WYTE, SAMUEL M. ROSS and BRIAN F. HOFFMAN
    Circulation Research. 1967;21:375-390, originally published September 1, 1967
    https://doi.org/10.1161/01.RES.21.3.375

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    Post-Countershock Arrhythmias in Untreated and Digitalized Dogs
    ROBERT E. TEN EICK, STEVEN R. WYTE, SAMUEL M. ROSS and BRIAN F. HOFFMAN
    Circulation Research. 1967;21:375-390, originally published September 1, 1967
    https://doi.org/10.1161/01.RES.21.3.375
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