Vascular and Extravascular Volumes of the Kidney of Man
Indicator dilution techniques were used to determine the vascular and extravascular volumes of the normal human kidney. Renal volumes were corrected to 1.73 m2 and refer to one kidney. The renal blood volume (VIG) averaged 34.8±3.1 ml; the water contained in the distribution volume of labeled inulin (VINW) averaged 48.8±9.0 ml, and that of tritiated water (VTHOW) 152±20 ml. VINW was used as an index of the extracellular space of the kidney exclusive of the tubular lumina. VTHOW was interpreted to represent the total exchangeable water content of the kidney. The interstitial volume (ΔVINTW) and tubular-cellular volume (ΔVCW) were derived and averaged 27.4±6.2 ml and 93.7±14.3 ml, respectively.
Correction for recirculation by exponential extrapolation was studied and appears satisfactory. Evidence is presented for the existence of significant fluctuations in renal blood flow during the indicator collection intervals, and it is suggested that renal volumes be based on flows determined from the recoveries of each indicator.
- indicator dilution studies
- inulin renal extracellular volume
- renal blood volume
- creatinine renal water volume
- renal blood flow
- indocyanine green tritiated water
- Accepted December 1, 1966.
- © 1967 American Heart Association, Inc.