Catecholamine Metabolism in Experimental Hypertension in the Rat
The role of catecholamines was investigated in uninephrectomized Sprague-Dawley male rats made hypertensive by administration of desoxycorticosterone and a high salt diet. The accumulation of tritiated norepinephrine and the endogenous norepinephrine levels were measured in the various organs. The content of endogenous norepinephrine and the accumulation of 3H-norepinephrine 1 hour after its injection were reduced in the heart, spleen, intestine, skeletal muscle, and kidney of hypertensive rats as compared to controls. Simultaneously, an increase in total 3H-metabolites was also found in the hypertensive animals.
A highly significant inverse relation was established between the level of blood pressure and the accumulation of 3H-norepinephrine or endogenous norepinephrine levels in the heart.
The abnormalities observed in the disposition of exogenously administered and endogenous norepinephrine do not appear to be secondary to a change in the distribution of cardiac output to the various organs. Since the initial uptake was normal in the hypertensive rats, the reduced capacity to accumulate norepinephrine seems to be related to a defect in the storage of norepinephrine.
- DOCA and salt hypertension systolic blood pressuore
- fractional blood flow uptake and binding of 3H-norepinephrine
- endogenous norepinephrine isolated perfused heart
- uninephrectomized rats
- Accepted November 28, 1966.
- © 1967 American Heart Association, Inc.