Development of Atherosclerosis in Dogs with Hypercholesterolemia and Chronic Hypertension
Hypercholesterolemia was induced in pure-bred dogs by cholesterol feeding and propylthiouracil or radioiodine. Hypertension induced by the injection of silica into the renal artery increased the severity of aortic atherosclerosis. Marked hypercholesterolemia increased the severity of aortic atherosclerosis even in normotensive dogs.
- © 1954 American Heart Association, Inc.