The Pattern of Recovery of Renal Function Following Renal Artery Occlusion in the Dog
The pattern of recovery of renal function following two hours of complete ischemia was studied in a series of dogs. A marked functional ischemia persisted for several hours after release of the clamp, but restoration of blood flow was substantially complete in 24 hours. Other renal functions returned slowly over a period of weeks, reflecting the rate of repair of damaged tubules. Two important phases of recovery are thus to be considered: (a) a brief but significant period of continuing ischemia immediately following the trauma, and (b) a period of slow repair of those nephrons damaged but not destroyed in the first phase of the insult.
- Received January 25, 1954.
- © 1954 American Heart Association, Inc.