Renal Inhibition of Pressor Responses to Drugs
Bilateral nephrectomy selectively augments reactivity to pressor drugs and affects that to angiotonin the most prominently. This change is not mediated through the central nervous system, does not depend upon mechanical exclusion of the renal vascular bed, and is not modified by change in sodium intake. The inhibitory action on pressor responsiveness is independent of renal excretory function.
- Received July 23, 1953.
- © 1954 American Heart Association, Inc.