Disturbances of Rhythm in the Cold-Blooded Heart Under Aconitine
The cold-blooded auricle under aconitine shows an early profound depression in rhythmicity but recovers in from 5 to 10 minutes to develop a high rate of spontaneous beating which may be considered a tachycardia for this preparation. Although arrhythmias do not appear spontaneously, a single, properly-timed stimulus to the auricle under aconitine initiates a multiple response which appears like ordinary fibrillation or flutter. The alterations in fundamental properties of the auricle which are required to elicit multiple responses favor a re-entrant rather than a focal mechanism of the induced arrhythmia.
- Received July 8, 1953.
- © 1954 American Heart Association, Inc.