Cardiovascular Effects of Sustained Norepinephrine Infusions. III. Lactic Dehydrogenase Isoenzyme Release
Infusion of norepinephrine (NE) in dogs in doses of 1 to 4 µg/kg/min resulted in a rapid and dose related increase in serum lactic dehydrogenase (LDH) and those isoenzymes of LDH present in the heart. Histochemically definable lesions in the heart were correlated with the isoenzyme release produced by 2 and 4 µg/kg/min NE infusion.
Evidence of LDH isoenzyme release from organs other than the heart was found only in dogs in the highest dose group that, in addition, had evidence of low cardiac output.
- Accepted November 19, 1965.
- © 1966 American Heart Association, Inc.