Detection of Preformed Venous Thrombi in Dogs by Means of I131-Labeled Antibodies to Dog Fibrinogen
Dogs with thrombin-induced thrombi received I131 rabbit antibody to dog fibrinogen and a day later were given antiserum to the rabbit gamma globulin. Scintillation scanning techniques successfully detected the site of thrombosis. Excision of the thrombi and surrounding blood vessels demonstrated deposition of radioactivity in the lesion. The immunologic removal of the gamma globulin from the circulating blood increased the difference between the radioactivity deposited in the lesion and that present in the blood. This accentuates the lesion and offers potential diagnostic advantage.
- Accepted March 26, 1965.
- © 1965 American Heart Association, Inc.