Metabolism of Atherosclerotic Tissue of Rabbit and Dog, with Special Reference to Esterase and Lipase
Esterase and lipase were studied in the aorta, liver, and serum of dogs and rabbits on an atherogenic diet. With the exception of dog serum, lipase was not present in any of the tissues studied.
At a relatively early stage the atherosclerotic intima-media layer, separated at the cleavage plane, showed increased esterase activity in both animals. At later stages, a reverse trend was noted in the rabbit, whereas in the dog, the esterase activity remained markedly increased. No pre-atherosclerotic enzymatic changes were noted.
The liver of both species showed increased esterase activity first and reversal to normal values later. In contrast, rabbit serum displayed no change for several months and decreased activity subsequently whereas in the dog, decreased esterase activity was noted throughout the administration of the atherogenic diet. Lipase activity in dog serum, which was unaffected for several months, decreased later.
Our results expand previous findings with other arterial enzymes and indicate further that metabolic alterations of the arterial wall are associated with the development of atherosclerosis.
- © 1965 American Heart Association, Inc.