Contribution of Intravascular Receptors to the Renal Responses Following Intravascular Volume Expansion
The renal responses to acute isotonic, isooncotic intravascular volume expansion have been studied in the normal dog, the vagotomized dog, and the dog with carotid sinus denervation. It was observed that either vagotomy or carotid sinus denervation attenuates significantly the diuretic response to intravascular volume expansion without influencing significantly the natriuretic response. The results indicated that carotid sinus receptors and receptors which have afferent fibers in the vagus nerves contribute substantially to the control of plasma volume by a mechanism which influences free water excretion. The receptors of the low pressure system probably play a primary role under conditions of hypervolemia while receptors of the high pressure system appear to play a primary role under conditions of hypovolemia.
- Accepted January 18, 1965.
- © 1965 American Heart Association, Inc.