Induced Pressure Gradients Across Infundibular Zone of Right Ventricle in Normal Dogs
In these experiments we have demonstrated that:
1. Right ventricular outflow-tract pressure gradients of significance can be induced in normal dogs by a sympathomimetic amine which increases the rate and force of ventricular contraction.
2. Such outflow-tract pressure gradients are magnified by the addition of other inotropic drugs, such as acetyl strophanthidin and calcium chloride.
3. These outflow-tract pressure gradients are not the result of an increase in the volume and rate of blood flow but are due to forceful contraction of the infundibulum.
- Received August 7, 1964.
- © 1965 American Heart Association, Inc.