Letter by Rupp and Jux Regarding Article, “Mechanisms of Cardiac Repair and Regeneration”
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To the Editor:
The review article “Mechanisms of Cardiac Repair and Regeneration” by Broughton et al1 overviews several pivotal aspects of biological processes impinging on cardiac maintenance, repair, and regeneration. A main message of the article is that aging is associated with an impairment of cardiac reparative and regenerative potential. As summarized, data of reparative and regenerative capacity in children is sparse, especially on a histological or cellular level. However, clinical courses of several cardiac diseases differ significantly in children compared with adults. In contrast to an inefficient cardiac recovery in adults, a significant recovery of cardiac function is documented in children in several courses. This letter should serve as an extension of the review from Broughton et al, underlining the impressive potential of recovery of young children hearts.
Cardiomyogenesis in the adult mammalian heart remains a rare and …