Letter by Mitchell et al Regarding Article, “Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment”
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To the Editor:
We would like to thank Dr Grosser et al1 for their continued interest in our work. While we may not agree with their arguments or their opinions of our study,2 we welcome debate in this extremely important area. We take this opportunity to address the points that they raise.
First, although urine may well be a convenient compartment within which to measure markers of prostacyclin and thromboxane A2, numerous observations,3–10 of which ours is only the latest,2 indicate that they poorly reflect production within the circulation and the reactivities of endothelial cells and platelets.
Second, the literature that Grosser et al1 cite is somewhat selective and in places inaccurate. For example, reference 3,11 which the authors cite to substantiate the statement “Most insights into the in vivo biology and pharmacology of the prostaglandin pathway have derived from the …