A Biomarker Ocular
Circulating MicroRNAs Toward Diagnostics for Acute Ischemic Stroke
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Despite the routine use of computed tomographic scans and magnetic resonance imaging, the diagnosis of stroke remains challenging because ≈50% of patients with acute ischemic stroke (IS) lack abnormalities in the computed tomographic and magnetic resonance imaging scans. There is an unmet need for new markers that support clinicians in the diagnosis of IS. Moreover, markers of prognosis would be of considerable interest because of the potential to guide secondary preventive therapies enabling personalized treatment.
Article, see p 970
Biomarkers play an important role in the definition, the acute triage, and the prognostic implications in clinical practice. A biomarker is a characteristic that is objectively measured and evaluated as an indicator of normal and pathogenic processes or pharmacological responses, and the expectation of a biomarker is to enhance the ability of the clinician to optimally manage the patients.1 Tremendous efforts have been put into in the identification and implementation of novel biomarkers in the vascular field,2 not only for proteins but also for emerging molecules such as noncoding RNAs, in particular microRNAs (miRNAs).3,4 miRNAs are small sequences of endogenous RNA molecules that function as important global regulators of gene expression and play key roles in many biological processes and diseases.5 Because of their remarkable stability in biological fluids6 and their tissue specificity, there is a great interest in the establishment of miRNAs as circulating biomarkers.
In this issue of Circulation Research, Tiedt et al7 evaluated circulating miRNAs as diagnostic biomarkers for acute IS and comprehensively investigated the potential clinical use of selected miRNAs. The authors used a step-wise approach of discovery, …