Response by Komarova et al to Letter Regarding Article, “Protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability”
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We thank Horowitz for the interesting points concerning our review on protein interactions at endothelial junctions and their role in regulating endothelial permeability.1 Unfortunately, in a review as broad as this, it is not possible to cite all important works in this field.
We agree with Horowitz that tight junctions (TJs) are ubiquitous adhesion complexes in endothelial cells and have, therefore, been extensively discussed in our review, particularly with reference to the blood–brain barrier. We also agree that endothelial adherens junctions (AJs) are studied in much greater detail. This should come as no surprise because multiple lines of evidence indicate that VE-cadherin adhesion, the main adhesion complex of AJs, is not only required but also sufficient to restrict permeability of the endothelial barrier …