Letter by Karlstaedt and Taegtmeyer Regarding Article, “Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy”
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To The Editor:
We have read with interest the article by Zhou et al.1 The authors demonstrated that in cardiomyocytes, conditional deletion of glycogen synthase kinase-3 (GSK-3) isoforms A and B leads to development of severe dilated cardiomyopathy. Zhou et al1 also report that GSK-3 suppresses cell cycle induction and that the subsequent loss of cardiac myocytes leads to impaired contractile function, development of dilated cardiomyopathy, and death. These are exciting findings, which are in agreement with …