The authors of the Circulation Research article by Izumiya et al (Apoptosis Signal-Regulating Kinase 1 Plays a Pivotal Role in Angiotensin II–Induced Cardiac Hypertrophy and Remodeling. Circ Res. 2003;93:9 874–883. doi: 10.1161/01.RES.0000100665.67510.F5) have requested a correction to address concerns raised on an anonymous Japanese Doctor’s blog.
Based upon these allegations, the authors’ institution, the Graduate School of Medical Sciences, Kumamoto University, investigated this issue. During this investigation, the authors provided all original source files for the figure in question, along with additional corroborative data, and the institution recommended publication of a corrected Figure 4.
The corrected Figure is provided below. In this experiment, the authors prepared 26 total transverse heart sections (WT=6, ASK1-/-=6, WT+AngII=7, ASK1-/-+AngII=7) on November 21, 2002. After checking the original source files, the authors noticed that the panels shown in the original Figure 4A were incorrectly selected during the preparation of the artwork. The panel showing ASK1-/- mouse was a duplicate of that showing WT mouse (original “WT 2” file). Also, the “WT 1” file was used for the panel showing WT+Ang II, and the “WT AII 7 “ file was used for the panel showing ASK1-/- + Ang II.
The authors assert that measurements and calculations were not affected by this artwork-selection mistake, and therefore this mistake did not affect any of the conclusions of this manuscript.
The authors apologize for this error, and the error has been noted and corrected in the online version of the article, which is available at http://circres.ahajournals.org/content/93/9/874.abstract
- © 2016 American Heart Association, Inc.