miR-33 and Hepatic Lipoprotein Secretion (p 10)
Allen et al advise against targeting miR-33 for decreasing atherosclerotic lesions.
MicroRNAs (miRs) are small RNAs—approximately 22 nucleotides in length—that bind to and suppress the expression of target mRNAs. A number of these have been implicated in regulating several cardiovascular processes. miR-33, for example has been reported to be pro-atherogenic and it has been shown that short-term suppression of this miR in mice increases plasma levels of HDL—the “good” cholesterol. However, contradictory results for miR-33 have also been reported, and now findings by Allen and colleagues support this contradiction. They found that long-term suppression of miR-33 in mice promoted liver secretion of very low-density lipoproteins (VLDLs), or “bad” cholesterol, and that, overexpression of miR-33 in hepatocytes reduced LDL secretion. The team showed that the mRNA encoding NSF, a key …