lncRNAs, Remodeling, and Heart Failure (p 1569)
Kumarswamy et al discover an RNA biomarker for heart failure.
Patients that survive a heart attack often develop cardiac remodeling and heart failure, but there are few indicators that help to determine which patients are most at risk. In cancer research, extracellular RNAs have been identified in blood plasma as potential biomarkers of disease. Whether heart failure patients might also have clinically informative plasma RNA profiles, however, has not been investigated. Thus, Kumarswamy and colleagues decided to analyze long non-coding RNAs in the plasma of patients who had suffered myocardial infarctions. Using ECG data, the team compared 15 patients who exhibited the most extreme heart remodeling with 15 who exhibited no remodeling at all. They found seven candidate RNAs that differed between these two extreme groups, but after examining the …