Abstract 273: Levels Of Vcam-1 Are Associated With Flow-mediated Dilation In Healthy African American Adults
Background: Vascular cell adhesion molecule-1 (VCAM-1) mediates the adhesion of monocytes to vascular endothelium, which play a role in the development of endothelial dysfunction and atherosclerosis. Flow-mediation dilation (FMD) is an endothelium-dependent response, which is mediated by nitric oxide and closely related to endothelial function. The purpose of the study was to test whether levels of VCAM-1 were associated the endothelial-dependent (FMD) in normotensive African Americans. Normotensives were studied in order to eliminate the influence of hypertension.
Methods and Results: Blood was collected in 22 subjects aged 41-62 yrs with normal blood pressure (125.0 ± 9.1 mmHg) after 12 hr fast. Plasma was obtained by centrifugation within 15 min after collection in 4 degree. A commercially available solid phase sandwich enzyme linked immuno-sorbent assay kit was used to detect VCAM-1 levels in plasma. FMD was measured after 5-min cuff occlusion using Doppler ultrasound. The maximum FMD diameters were calculated. In the entire study population, levels of VCAM-1 (556.92 ± 154.20 ng/mL) were negatively correlated with the true peak FMD (FMD: 7.81 ± 2.22 %, r=-0.484, P=0.023).
Conclusion: Levels of VCAM-1 were associated with endothelial responsiveness in healthy African Americans with normal blood pressure. These results suggest that the level of VCAM-1 may be a predictive of endothelial dysfunction in the unique healthy populations.
- © 2013 by American Heart Association, Inc.