Abstract 034: The Effect Of Simvastatin On P-wave Dispersion And Echocardiographic Parameters Among Hypertensive Patients
Introduction: Rising evidence suggests that statins have a positive effect on the prevention of occurrence of atrial fibrillation (AF) in hypertensive patients. P-wave dispersion (PWD) has been known to be an electrocardiographic predictor for the development of AF. We therefore aimed to investigate on the possible effects of statins on p-wave dispersion in hypertensive patients.
Method: A total of 27 patients (22 females; mean age, 45±11 years) with hypertension and without history of AF were included in this prospective study. P wave durations and PWD, left ventricular mass (LVMI), left atrial volume index (LAVI), and ratio of early diastolic transmitral flow velocity (E) to early diastolic mitral annular velocity (e) (E/e’) were measured and compared before and after statin therapy (simvastatin 40mg/day for 3 months).
Results: After 3 months of statin therapy, there was no significant change in PWD (pre-statin 39.7 ±10.7, post-statin 33 ± 8.8, p-value 0.30). Baseline and follow up blood pressure, heart rate, LVMI, LAVI and E/e’ ratio were not significantly different before and after simvastatin therapy. No patient developed AF during follow up.
Conclusion: Simvastatin (40mg/day) therapy for 3 months did not show significant change on PWD, LVMI, LAVI and E/e’ ratio in hypertensive patients.
- © 2013 by American Heart Association, Inc.